A Solventless Protocol for the Michael Addition of Aromatic Amides to α,β-Unsaturated Esters Promoted by Microwave Irradiation

A. Zare^a,, A. Hasaninejad^b,, A. Khalafi-Nezhad^c, A. Parhami^c and A.R. Moosavi Zare^c

^aDepartment of Chemistry, Payame Nour University of Bushehr, Bushehr 1698, Iran
^bDepartment of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr 75169, Iran
^cDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran

A very simple and efficient solvent-free method for the preparation of N-benzoylated β-amino esters (protected β-amino acids) via the microwave-assisted Michael addition of aromatic amides to α,β-unsaturated esters in the presence of Cs₂CO₃and tetrabutylammonium bromide (TBAB) is described. The advantages of this method are efficiency, high yields and short reaction times.

Keywords: Michael addition,Amide, α,β-Unsaturated ester, Microwave, Protected β-amino acid

A Solventless Protocol for the Michael Addition of Aromatic Amides to α,β-Unsaturated Esters Promoted by Microwave Irradiation

A. Zarea,*, A. Hasaninejadb,*, A. Khalafi-Nezhadc, A. Parhamic and A.R. Moosavi Zarec

aDepartment of Chemistry, Payame Nour University of Bushehr, Bushehr 1698, Iran bDepartment of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr 75169, Iran cDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran

A. Zare^a,, A. Hasaninejad^b,, A. Khalafi-Nezhad^c, A. Parhami^c and A.R. Moosavi Zare^c

^aDepartment of Chemistry, Payame Nour University of Bushehr, Bushehr 1698, Iran
^bDepartment of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr 75169, Iran
^cDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran