Fe(HSO₄)₃as an Efficient Catalyst for the Preparation of 3,4-Dihydropyrimidin- 2(1H)-ones in Solution and under Solvent-Free Conditions

F. Shirini^a,, M.A. Zolfigol^b and A.-R. Abri^a*

^aDepartment of Chemistry, College of Science, University of Guilan, Rasht, zip code 41335, I. R. Iran
^bFaculty of Chemistry, Bu-Ali Sina University, Hamadan, 6517838683, Iran

A one-pot three-component condensation of aromatic aldehydes, β-ketoesters and urea or thiourea, efficiently promoted in the presence of Fe(HSO₄)₃ in solution and under solvent-free conditions, produced 3,4-dihydropyrimidin-2(1H)-ones. The method offers several advantages including simple, easy and clean work-up procedure, relatively short reaction times and good to high yields of the products

Keywords: 3,4-Dihydropyrimidin-2(1H)-ones, Solvent-free conditions, Biginelli reaction, Three-component condensation, Fe(HSO₄)₃

Fe(HSO4)3 as an Efficient Catalyst for the Preparation of 3,4-Dihydropyrimidin- 2(1H)-ones in Solution and under Solvent-Free Conditions

F. Shirinia,*, M.A. Zolfigolb and A.-R. Abria

aDepartment of Chemistry, College of Science, University of Guilan, Rasht, zip code 41335, I. R. Iran bFaculty of Chemistry, Bu-Ali Sina University, Hamadan, 6517838683, Iran

Fe(HSO₄)₃as an Efficient Catalyst for the Preparation of 3,4-Dihydropyrimidin- 2(1H)-ones in Solution and under Solvent-Free Conditions

F. Shirini^a,, M.A. Zolfigol^b and A.-R. Abri^a*

^aDepartment of Chemistry, College of Science, University of Guilan, Rasht, zip code 41335, I. R. Iran
^bFaculty of Chemistry, Bu-Ali Sina University, Hamadan, 6517838683, Iran