J. Iran. Chem. Soc., Vol. 4, No. 4 December 2007, pp.467~475.
Current location: JICS Archive > Vol. 4 > No. 4 > Articles : 11
Microwave-Assisted Michael Addition of Sulfonamides to α,β-Unsaturated Esters: A Rapid Entry to Protected b-Amino Acid Synthesis
G.H. Imanzadeha, A. Zareb,*, A. Khalafi-Nezhadc,*, A. Hasaninejadd, A.R. Moosavi Zarea and A. Parhamic
aDepartment of Chemistry, Faculty of Basic Sciences, Mohagheghe Ardebili University, Ardebil 179, Iran
bDepartment of Chemistry, Payame Nour University of Bushehr, Bushehr 1698, Iran
cDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran
dDepartment of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr 75169, Iran
An efficient, clean and very simple procedure for the synthesis of protected β-amino acids is described. Michael addition of sulfonamides to α,β-unsaturated esters in the presence of K2CO3 and tetrabutylammonium bromide (TBAB) under microwave irradiation affords the title compounds in good to high yields and short reaction times. This new method affords protected β-amino acids in high yields and short reaction times.
Keywords: Microwave, Michael addition, Sulfonamide, α,β-Unsaturated ester, β-Amino acid
