Highly Regioselective N-Alkylation of Benzotriazole under Solvent-Free Conditions

A. Khalafi-Nezhad^a,, A. Zare^b,, A. Parhami^a, M.N. Soltani Rad^c and G.R. Nejabat^a

^aDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran
^bDepartment of Chemistry, Payame Nour University of Bushehr, Bushehr 1698, Iran
^cDepartment of Chemistry, College of Basic Sciences, Shiraz University of Technology, Shiraz 71555-313, Iran

An efficient, simple and solvent-free method for highly regioselective N-alkylation of benzotriazole in the presence of SiO₂, K₂CO₃ and tetrabutylammonium bromide (TBAB) under thermal and microwave conditions has been described. In this method, 1-alkyl benzotriazoles were obtained regioselectively in moderate to high yields and short reaction times.

Keywords: N-Alkylation, Benzotriazole, Solvent-free, Thermal, Microwave

Highly Regioselective N-Alkylation of Benzotriazole under Solvent-Free Conditions

A. Khalafi-Nezhada,*, A. Zareb,*, A. Parhamia, M.N. Soltani Radc and G.R. Nejabata

aDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, IranbDepartment of Chemistry, Payame Nour University of Bushehr, Bushehr 1698, IrancDepartment of Chemistry, College of Basic Sciences, Shiraz University of Technology, Shiraz 71555-313, Iran

A. Khalafi-Nezhad^a,, A. Zare^b,, A. Parhami^a, M.N. Soltani Rad^c and G.R. Nejabat^a

^aDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran
^bDepartment of Chemistry, Payame Nour University of Bushehr, Bushehr 1698, Iran
^cDepartment of Chemistry, College of Basic Sciences, Shiraz University of Technology, Shiraz 71555-313, Iran