J. Iran. Chem. Soc., Vol. 4, No. 3 September 2007, pp.370~374.
Current location: JICS Archive > Vol. 4 > No. 3 > Articles : 14
Molecular Iodine-Catalyzed Efficient N-Cbz Protection of Amines
R. Varala, R. Enugala and S.R. Adapa*
Indian Institute of Chemical Technology, Hyderabad-500 007, India
An efficient and selective protection of various structurally and electronically divergent aryl and aliphatic amines with Cbz-Cl in the presence of a catalytic amount of molecular iodine (2 mol%) in methanol with high yields at ambient temperature is presented.
Keywords: Molecular iodine, Catalysis, Amine protection, Cbz-Cl
