Michael Addition of Phthalimide and Saccharin to α,β-Unsaturated Esters Under Solvent-Free Conditions

G.H. Imanzadeh^a,, A. Khalafi-Nezhad^b,, A. Zare^c,, A. Hasanineja^d, A.R. Moosavi Zare^a, A. Parhami^b*

^aDepartment of Chemistry, Faculty of Basic Sciences, Mohagheghe Ardebili University, Ardebil 179, Iran
^bDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran
^cDepartment of Chemistry, Payame Nour University of Bushehr, Bushehr 1698, Iran

An efficient, clean and simple procedure for the Michael addition of phthalimide and saccharin to various α,β-unsaturated esters in the presence of tetrabutylammonium bromide (TBAB) and 1,4-diazabicyclo[2,2,2]octane (DABCO) under solvent-free conditions is described. By this method, the Michael adducts are obtained in good to excellent yields in short reaction times under thermal and microwave conditions.

Keywords: Michael addition, Phthalimide, Saccharin, α,β-Unsaturated esters, Solvent-free

Michael Addition of Phthalimide and Saccharin to α,β-Unsaturated Esters Under Solvent-Free Conditions

G.H. Imanzadeha,*, A. Khalafi-Nezhadb,*, A. Zarec,*, A. Hasaninejad, A.R. Moosavi Zarea, A. Parhamib

aDepartment of Chemistry, Faculty of Basic Sciences, Mohagheghe Ardebili University, Ardebil 179, IranbDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, IrancDepartment of Chemistry, Payame Nour University of Bushehr, Bushehr 1698, Iran

G.H. Imanzadeh^a,, A. Khalafi-Nezhad^b,, A. Zare^c,, A. Hasanineja^d, A.R. Moosavi Zare^a, A. Parhami^b*

^aDepartment of Chemistry, Faculty of Basic Sciences, Mohagheghe Ardebili University, Ardebil 179, Iran
^bDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran
^cDepartment of Chemistry, Payame Nour University of Bushehr, Bushehr 1698, Iran