Reductive Amination of Aldehydes with Sodium Borohydride and Lithium Aluminum Hydride in the Presence of Lithium Perchlorate

M.R. Saidi^a,, R. Stan Brown^b,* and A. Ziyaei-Halimjani^a*

^bDepartment of Chemistry, Queen's University, Kingston, Ontario, Canada
^aDepartment of Chemistry, Department of Chemistry, Sharif University of Technology, P.O. Box 11365-9516 Tehran, Iran

A one-pot high yielding reductive amination of aldehydes with primary and secondary amines using LiClO₄/NaBH₄ and LiClO₄/LiAlH₄ as reducing agents in diethyl ether is described.

Keywords: Reductive amination, Sodium borohydride, Lithium aluminum hydride, Lithium perchlorate, Aldehyde

Reductive Amination of Aldehydes with Sodium Borohydride and Lithium Aluminum Hydride in the Presence of Lithium Perchlorate

M.R. Saidia,*, R. Stan Brownb,* and A. Ziyaei-Halimjania

bDepartment of Chemistry, Queen's University, Kingston, Ontario, CanadaaDepartment of Chemistry, Department of Chemistry, Sharif University of Technology, P.O. Box 11365-9516 Tehran, Iran

M.R. Saidi^a,, R. Stan Brown^b,* and A. Ziyaei-Halimjani^a*

^bDepartment of Chemistry, Queen's University, Kingston, Ontario, Canada
^aDepartment of Chemistry, Department of Chemistry, Sharif University of Technology, P.O. Box 11365-9516 Tehran, Iran