Synthesis and Immunomodulatory Activity of Some Novel Amino Acid Germinates

A.M. Badawi and A.A. Hafiz*

Applied Surfactant Laboratory, Egyptian Petroleum Research Institute (EPRI) Nasr City, Cairo, Egypt

Amino acid germanate compounds are synthesized by the chemical reaction of germanium dioxide with a selected amino acid in the presence of an alkali medium at a suitable elevated temperature. Amino acids included in the novel synthesis include histidine, methionine and glutathione. The study evaluated their effects on induction of interleukin-12 and interferon-γ in Swiss albino Webster rats. The new germanium compounds, especially bis-methionino germanate, are considered as good interferon inducer that significantly enhance the immunologic function.

Keywords: Amino acid germanate-immunomodulatory, Interferon-γ, Interleukin-12