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Neat Reaction Technology for the Synthesis of 4-Oxo-thiazolidines Derived from 2-SH-Benzothiazole and Antimicrobial Screening of Some Synthesized 4-Thiazolidinones†

K.G. Desai ^a,*, J.P. Raval^b and K.R. Desai^c

^aDepartment of Chemistry, Faculty of Science, Synthetic Organic Chemistry Research Laboratory, Veer Narmad South Gujarat University, Surat, Gujarat State, India
^bIndustrial Chemistry Division, Department of Chemistry, V.N.S.G. University, Surat, Gujarat State, India
^cChemistry Department, Organic Chemistry Division, Faculty of Science, V. N.S.G. University, Surat, Gujarat State, India

The synthesis of 4-thiazolidinones 4a-j in a good yields from the heterocyclization reaction of 2-(benzothiazol-2-ylthio)-N’-benzylideneacetohydrazide 3a-j with SHCH₂COOH in DMF in the presence of a catalytic amount of anhydrous ZnCl₂ under microwave irradiation is described and compared with conventional synthesis methods. All structures of the newly synthesized compounds were elucidated by elemental analysis and spectral data. Some of the new compounds were tested against bacteria (Gram- ve and Gram+ ve) and fungi.

Keywords: 4-Thiazolidinones, Heterocyclization, Microwave effect, Antimicrobial activity