J. Iran. Chem. Soc., Vol. 3, No. 1 March 2006, pp.89~92.
Current location: JICS Archive > Vol. 3 > No. 1 > Articles : 12
One-Pot Facile Conversion of Baylis-Hillman Adducts into 1,5-Diarylpyrazoles Using Microwave Irradiation
M. Mamaghani*, K. Tabatabaeian, M. Mirzaeinejad and M. Nikpassand
Department of Chemistry, Faculty of Sciences,University of Guilan,
Rasht, Iran
Several Baylis-Hillman adducts were prepared by the reaction of appropriate arylaldehydes with methyl vinyl ketone in the presence of imidazole and a catalytic amount of L-proline, in 55-90% yields. An easy transformation of these adducts into 1,5-diarylpyrazoles was achieved using microwave irradiation (400 W) with short reaction times (1-3 min) and high yields (80-91%).
Keywords: Baylis-Hillman, 1,5-Diarylpyrazole, Microwave
