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One Pot Synthesis of Side Chain Fluorinated Heterocyclic Compounds by Microwave Irradiation

H. Loghmani-Khouzani*, M.M. Sadeghi and R. Ranjbar-Karimi

Department of Chemistry, Isfahan University, Isfahan 81746-73441, Iran

2- Or 4-Difluoronitromethyl and 2- or 4-fluoronitrobenzyl substituted pyridines, quinolines, phenantheridine, benzothiazol and benzoxazol were synthesized by reaction of the corresponding nitro compounds in the presence of 1-chloromethyl-4-fluoro-1,4-diazoiabicyclo[2,2,2]octane bis(tetrafluoroborate) (Select-Fluor) and ammonium acetate as a base under microwave irradiation. This method is very efficient and the yields were significantly improved in comparison to the previous reports.

Keywords: Heterocyclic compounds, Ammonium acetate, Select-Fluor, Fluorination, Organofluorine, Microwave