J. Iran. Chem. Soc., Vol. 2, No. 4 December 2005, pp.289~293.
Current location: JICS Archive > Vol. 2 > No. 4 > Articles : 2
A New Synthesis of 1,3-Aminols from Direct Double Reduction
of β-Enamino Ketones Formed in situ by Reaction of β-Dicarbonyl
Compounds with Anilines
M.M. Khodaei*, A.R. Khosropour* and J. Abassi
Department of Chemistry, Razi University, Kermanshah 67149, Iran
A new one-pot synthesis of 1,3-aminols by direct reduction of β-enamino ketones, formed in situ by reaction of easily available β-dicarbonyl compounds, with anilines were described. In the case of aliphatic amines such as benzyl amine, n-butyl amine and β-hydroxy ethyl amine, the corresponding 1,3-minols were not obtained. In fact, the β-enamino ketone formed was failed to accomplish further reduction to 1,3-aminol. This approach is the most direct available method for the synthesis of 1,3-aminols.
Keywords: 1,3-Aminols, β-Enamino ketones, β-Dicarbonyls, Anilines, NaBH4
